TY  - JOUR
A1  - Hilmi, Dina
A1  - Parcina, Marijo
A1  - Stollewerk, Daniel
A1  - Ostrop, Jenny
A1  - Josten, Michaele
A1  - Meilaender, Alina
A1  - Zähringer, Ulrich
A1  - Wichelhaus, Thomas Alexander
A1  - Bierbaum, Gabriele
A1  - Heeg, Klaus
A1  - Wolz, Christiane
A1  - Bekeredjian-Ding, Isabelle
T1  - Heterogeneity of host TLR2 stimulation by staphylocoocus aureus isolates
T2  - PLoS One
N2  - High lipoprotein expression and potent activation of host Toll-like receptor-2 (TLR2) are characteristic features of the staphylococcal species. Expression of TLR2 in the host is important for clearance of Staphylococcus aureus infection and host survival. Thus, we hypothesized that bacterial regulation of its intrinsic TLR2-stimulatory capacity could represent a means for immune evasion or host adaptation. We, therefore, compared clinical S. aureus isolates in regards to their TLR2 activation potential and assessed the bacterial factors that modulate TLR2-mediated recognition. S. aureus isolates displayed considerable variability in TLR2-activity with low to absent TLR2-activity in 64% of the isolates tested (68/106). Notably, strain-specific TLR2-activity was independent of the strain origin, e.g. no differences were found between strains isolated from respiratory specimen from cystic fibrosis patients or those isolated from invasive disease specimen. TLR2-activity correlated with protein A expression but not with the agr status. Capsule expression and small colony variant formation had a negative impact on TLR2-activity but any disruption of cell wall integrity enhanced TLR2 activation. Altogether, heterogeneity in host TLR2-activity reflects differences in metabolic activity and cell wall synthesis and/or remodeling.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/33795
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-337954
SN  - 1932-6203
N1  - Copyright: © 2014 Koss et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - (5):e96416
PB  - PLoS
CY  - Lawrence, Kan.
ER  -