TY  - JOUR
A1  - Stölzel, Friedrich
A1  - Mohr, Brigitte
A1  - Kramer, Michael
A1  - Oelschlägel, Uta
A1  - Bochtler, Tilmann
A1  - Berdel, Wolfgang E.
A1  - Kaufmann, Martin
A1  - Baldus, Claudia
A1  - Schäfer-Eckart, Kerstin
A1  - Stuhlmann, Reingard
A1  - Einsele, Hermann
A1  - Krause, Stefan W.
A1  - Serve, Hubert
A1  - Hänel, Mathias
A1  - Herbst, Regina
A1  - Neubauer, Andreas
A1  - Sohlbach, Kristina
A1  - Mayer, Jiri
A1  - Middeke, Jan Moritz
A1  - Platzbecker, Uwe
A1  - Schaich, Markus
A1  - Krämer, Alwin
A1  - Röllig, Christoph
A1  - Schetelig, Johannes
A1  - Bornhäuser, Martin
A1  - Ehninger, Gerhard
T1  - Karyotype complexity and prognosis in acute myeloid leukemia
T2  - Blood cancer journal
N2  - A complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our study demonstrated that (1) patients with a pure hyperdiploid karyotype have an adverse risk irrespective of the number of chromosomal gains, (2) patients with translocation t(9;11)(p21~22;q23) have an intermediate risk independent of the number of additional aberrations, (3) patients with greater than or equal to4 abnormalities have an adverse risk per se and (4) patients with three aberrations in the absence of abnormalities of strong influence (hyperdiploid karyotype, t(9;11)(p21~22;q23), CBF-AML, unique adverse-risk aberrations) have borderline intermediate/adverse risk with a reduced overall survival compared with patients with a normal karyotype.
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/41719
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-417198
SN  - 2044-5385
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
VL  - 6
IS  - e386
PB  - Nature Publishing Group
CY  - London [u.a.]
ER  -