TY  - JOUR
A1  - Mora, Javier
A1  - Mertens, Christina
A1  - Meier, Julia K.
A1  - Fuhrmann, Dominik Christian
A1  - Brüne, Bernhard
A1  - Jung, Michaela
T1  - Strategies to interfere with tumor metabolism through the interplay of innate and adaptive immunity
T2  - Cells
N2  - The inflammatory tumor microenvironment is an important regulator of carcinogenesis. Tumor-infiltrating immune cells promote each step of tumor development, exerting crucial functions from initiation, early neovascularization, to metastasis. During tumor outgrowth, tumor-associated immune cells, including myeloid cells and lymphocytes, acquire a tumor-supportive, anti-inflammatory phenotype due to their interaction with tumor cells. Microenvironmental cues such as inflammation and hypoxia are mainly responsible for creating a tumor-supportive niche. Moreover, it is becoming apparent that the availability of iron within the tumor not only affects tumor growth and survival, but also the polarization of infiltrating immune cells. The interaction of tumor cells and infiltrating immune cells is multifaceted and complex, finally leading to different activation phenotypes of infiltrating immune cells regarding their functional heterogeneity and plasticity. In recent years, it was discovered that these phenotypes are mainly implicated in defining tumor outcome. Here, we discuss the role of the metabolic activation of both tumor cells and infiltrating immune cells in order to adapt their metabolism during tumor growth. Additionally, we address the role of iron availability and the hypoxic conditioning of the tumor with regard to tumor growth and we describe the relevance of therapeutic strategies to target such metabolic characteristics.
KW  - tumor-associated macrophages
KW  - T cells
KW  - hypoxia
KW  - cancer cell metabolism
KW  - iron metabolism
KW  - iron chelator
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50317
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-503177
SN  - 2073-4409
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
VL  - 8
IS  - 5, Art. 445
SP  - 1
EP  - 20
PB  - MDPI
CY  - Basel
ER  -