TY  - JOUR
A1  - Silbernagel, Günther
A1  - Fauler, Guenter
A1  - Renner, Wilfried
A1  - Landl, Eva M.
A1  - Hoffmann, Michael Marcus
A1  - Winkelmann, Bernhard R.
A1  - Böhm, Bernhard O.
A1  - März, Winfried
T1  - The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease
T2  - Journal of lipid research
N2  - Changes in the balance of cholesterol absorption and synthesis and moderately elevated plasma plant sterols have been suggested to be atherogenic. Measuring cholestanol, lathosterol, campesterol, and sitosterol, we investigated the relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease (CAD) in 2,440 participants of the Ludwigshafen Risk and Cardiovascular health (LURIC) study. The coronary status was determined by angiography, and the severity of CAD was assessed by the Friesinger Score (FS). An increase in the ratio of cholestanol to cholesterol was associated with high FS (P = 0.006). In contrast, a high ratio of lathosterol to cholesterol went in parallel with low FS (P < 0.001). Whereas the campesterol to cholesterol ratio significantly correlated with the FS (P = 0.026), the relationship of the sitosterol to cholesterol ratio with the FS did not reach statistical significance in the whole group. Increased campesterol, sitosterol, and cholestanol to lathosterol ratios were associated high FS (P < 0.001). To conclude, there is a modest association of high cholesterol absorption and low cholesterol synthesis with an increased severity of CAD. An atherogenic role of plasma plant sterols themselves, however, seems unlikely in subjects without sitosterolaemia.
KW  - cholesterol absorption
KW  - cholesterol synthesis
KW  - phytosterols
KW  - campesterol
KW  - sitosterol
KW  - cholestanol
KW  - lathosterol
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76474
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-764743
SN  - 0022-2275
VL  - 50.2009
IS  - 2
SP  - 334
EP  - 341
PB  - American Society for Biochemistry and Molecular Biology Publications
CY  - Bethesda, Md
ER  -