TY - JOUR A1 - Bowen, Tom A1 - Cicardi, Marco A1 - Farkas, Henriette A1 - Bork, Konrad A1 - Longhurst, Hilary A1 - Zuraw, Bruce A1 - Aygören-Pürsün, Emel A1 - Craig, Timothy A1 - Binkley, Karen A1 - Hebert, Jacques A1 - Ritchie, Bruce A1 - Bouillet, Laurence A1 - Betschel, Stephen A1 - Cogar, Della A1 - Dean, John A1 - Devaraj, Ramachand A1 - Hamed, Azza A1 - Kamra, Palinder A1 - Keith, Paul K. A1 - Lacuesta, Gina A1 - Leith, Eric A1 - Lyons, Harriet A1 - Mace, Sean A1 - Mako, Barbara A1 - Neurath, Doris A1 - Poon, Man-Chiu A1 - Rivard, Georges-Etienne A1 - Schellenberg, Robert A1 - Rowan, Dereth A1 - Rowe, Anne A1 - Stark, Donald A1 - Sur, Smeeksha A1 - Tsai, Ellie A1 - Warrington, Richard A1 - Waserman, Susan A1 - Ameratunga, Rohan A1 - Bernstein, Jonathan A. A1 - Björkander, Janne A1 - Brosz, Kristylea A1 - Brosz, John A1 - Bygum, Anette A1 - Caballero, Teresa A1 - Frank, Mike A1 - Fust, George A1 - Harmat, George A1 - Kanani, Amin A1 - Kreuz, Wolfhart A1 - Levi, Marcel M. A1 - Li, Henry A1 - Martinez Saguer, Inmaculada A1 - Moldovan, Dumitru A1 - Nagy, Istvan A1 - Nielsen, Erik W. A1 - Nordenfelt, Patrik A1 - Reshef, Avner A1 - Rusicke, Eva A1 - Smith-Foltz, Sarah A1 - Späth, Peter A1 - Varga, Lilian A1 - Xiang, Zhi Yu T1 - 2010 international consensus algorithm for the diagnosis, therapy and management of hereditary angioedema T2 - Allergy, Asthma & Clinical Immunology N2 - Background We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Objective To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010). Methods The Canadian Hereditary Angioedema Network (CHAEN)/Reseau Canadien d'angioedeme hereditaire (RCAH) (www.haecanada.com) and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring) held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review. Results This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference. Conclusions Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management. Y1 - 2010 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/7883 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30-78325 N1 - © 2010 Bowen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. VL - 6 IS - 24 ER -