TY  - JOUR
A1  - Relja, Borna
A1  - Mörs, Katharina
A1  - Marzi, Ingo
T1  - Danger signals in trauma
T2  - European journal of trauma and emergency surgery
N2  - This review summarizes a short list of currently discussed trauma-induced danger-associated molecular patterns (DAMP). Due to the bivalent character and often pleiotropic effects of a DAMP, it is difficult to describe its “friend or foe” role in post-traumatic inflammation and regeneration, both systemically as well locally in tissues. DAMP can be used as biomarkers to indicate or monitor disease or injury severity, but also may serve as clinically applicable parameters for better indication and timing of surgery. Due to the inflammatory processes at the local tissue level or the systemic level, the precise role of DAMP is not always clear to define. While in vitro and experimental studies allow for the detection of these biomarkers at the different levels of an organism—cellular, tissue, circulation—this is not always easily transferable to the human setting. Increased knowledge exploring the dual role of DAMP after trauma, and concentrating on their nuclear functions, transcriptional targets, release mechanisms, cellular sources, multiple functions, their interactions and potential therapeutic targeting is warranted.
KW  - DAMP
KW  - Trauma
KW  - Injury
KW  - Biomarker
KW  - Inflammation
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/47702
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-477022
SN  - 1863-9941
SN  - 1863-9933
N1  - Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
VL  - 44
IS  - 3
SP  - 301
EP  - 316
PB  - Springer Medizin
CY  - Heidelberg
ER  -