TY  - JOUR
A1  - Eickel, Vera
A1  - Kahl, Barbara
A1  - Reinisch, Beatrice
A1  - Dübbers, Angelika
A1  - Küster, Peter
A1  - Brandt, Claudia
A1  - Spellerberg, Barbara
T1  - Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients
T2  - PLoS One
N2  - Streptococcus agalactiae is a well-known pathogen for neonates and immunocompromized adults. Beyond the neonatal period, S. agalactiae is rarely found in the respiratory tract. During 2002–2008 we noticed S. agalactiae in respiratory secretions of 30/185 (16%) of cystic fibrosis (CF) patients. The median age of these patients was 3–6 years older than the median age CF patients not harboring S. agalactiae. To analyze, if the S. agalactiae isolates from CF patients were clonal, further characterization of the strains was achieved by capsular serotyping, surface protein determination and multilocus sequence typing (MLST). We found a variety of sequence types (ST) among the isolates, which did not substantially differ from the MLST patterns of colonizing strains from Germany. However serotype III, which is often seen in colonizing strains and invasive infections was rare among CF patients. The emergence of S. agalactiae in the respiratory tract of CF patients may represent the adaptation to a novel host environment, supported by the altered surfactant composition in older CF patients.
Y1  - 2009
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/22613
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-114586
SN  - 1932-6203
N1  - Copyright: © 2009 Eickel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 4
IS  - (2): e4650
ER  -