TY  - JOUR
A1  - Fleischmann, Maximilian
A1  - Chatzikonstantinou, Georgios
A1  - Fokas, Emmanouil
A1  - Wichmann, Jörn
A1  - Christiansen, Hans
A1  - Strebhardt, Klaus
A1  - Rödel, Claus
A1  - Tselis, Nikolaos
A1  - Rödel, Franz
T1  - Molecular markers to predict prognosis and treatment response in uterine cervical cancer
T2  - Cancers
N2  - Uterine cervical cancer is one of the leading causes of cancer-related mortality in women worldwide. Each year, over half a million new cases are estimated, resulting in more than 300,000 deaths. While less-invasive, fertility-preserving surgical procedures can be offered to women in early stages, treatment for locally advanced disease may include radical hysterectomy, primary chemoradiotherapy (CRT) or a combination of these modalities. Concurrent platinum-based chemoradiotherapy regimens remain the first-line treatments for locally advanced cervical cancer. Despite achievements such as the introduction of angiogenesis inhibitors, and more recently immunotherapies, the overall survival of women with persistent, recurrent or metastatic disease has not been extended significantly in the last decades. Furthermore, a broad spectrum of molecular markers to predict therapy response and survival and to identify patients with high- and low-risk constellations is missing. Implementation of these markers, however, may help to further improve treatment and to develop new targeted therapies. This review aims to provide comprehensive insights into the complex mechanisms of cervical cancer pathogenesis within the context of molecular markers for predicting treatment response and prognosis.
KW  - cervical cancer
KW  - predictive
KW  - prognostic
KW  - molecular marker
KW  - biomarker
KW  - outcome
KW  - survival
KW  - response
KW  - chemoradiotherapy
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/82277
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-822772
SN  - 2072-6694
VL  - 13
IS  - 22, art. 5748
SP  - 1
EP  - 28
PB  - MDPI
CY  - Basel
ER  -