TY  - JOUR
A1  - Koch, Christine
A1  - Bambey, Cornelia
A1  - Filmann, Sonja Natalie
A1  - Stanke, Marc
A1  - Waidmann, Oliver
A1  - Husmann, Gabriele
A1  - Bojunga, Jörg
T1  - Survival according to therapy regimen for small intestinal neuroendocrine tumors
T2  - Journal of Clinical Medicine
N2  - Introduction: Scarce data exist for therapy regimens other than somatostatin analogues (SSA) and peptide receptor radiotherapy (PRRT) for siNET. We analyzed real world data for differences in survival according to therapy. Patients and methods: Analysis of 145 patients, diagnosed between 1993 and 2018 at a single institution, divided in treatment groups. Group (gr.) 0: no treatment (n = 10), gr 1: TACE and/or PRRT (n = 26), gr. 2: SSA (n = 32), gr. 3: SSA/PRRT (n = 8), gr. 4: chemotherapy (n = 8), gr. 5: not metastasized (at diagnosis), surgery only (n = 53), gr. 6 = metastasized (at diagnosis), surgery only (n = 10). Results: 45.5% female, median age 60 years (range, 27–84). A total of 125/145 patients with a resection of the primary tumor. For all patients, 1-year OS (%) was 93.8 (95%-CI: 90–98), 3-year OS = 84.3 (CI: 78–90) and 5-year OS = 77.5 (CI: 70–85). For analysis of survival according to therapy, only stage IV patients (baseline) that received treatment were included. Compared with reference gr. 2 (SSA only), HR for OS was 1.49 (p = 0.47) for gr. 1, 0.72 (p = 0.69) for gr. 3, 2.34 (p = 0.19) for gr. 4. The 5 y OS rate of patients whose primary tumor was resected (n = 125) was 73.1%, and without PTR was 33.3% (HR: 4.31; p = 0.003). Individual patients are represented in swimmer plots. Conclusions: For stage IV patients in this analysis (limited by low patient numbers in co. 3/4), multimodal treatment did not significantly improve survival over SSA treatment alone. A resection of primary tumor significantly improves survival.
KW  - delay
KW  - diagnosis
KW  - metastases
KW  - neuroendocrine
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/79810
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-798105
SN  - 2077-0383
N1  - The data presented in this study are available on request from the corresponding author. The data are not publicly available due to ethical and legal restrictions. Aleniated data used for the swimmer plot are stored in a public repository: https://gitlab.com/mstanke/swimmers_plot (accessed on 15 April 2022).
VL  - 11
IS  - 9, art. 2358
SP  - 1
EP  - 12
PB  - MDPI
CY  - Basel
ER  -