TY - JOUR A1 - Jasmer, Britta A1 - Muschol-Steinmetz, Cornelia A1 - Kreis, Nina-Naomi A1 - Friemel, Alexandra A1 - Kielland-Kaisen, Ulrikke A1 - Brüggmann, Dörthe A1 - Jennewein, Lukas A1 - Allert, Roman A1 - Solbach, Christine A1 - Yuan, Juping A1 - Louwen, Frank T1 - Involvement of the oncogene B-cell lymphoma 6 in the fusion and differentiation process of trophoblastic cells of the placenta T2 - OncoTarget N2 - The oncogene B-cell lymphoma 6 (BCL6) is associated with lymphomagenesis. Intriguingly, its expression is increased in preeclamptic placentas. Preeclampsia is one of the leading causes of maternal and perinatal mortality and morbidity. Preeclamptic placentas are characterized by various defects like deregulated differentiation and impaired fusion of trophoblasts. Its pathogenesis is however not totally understood. We show here that BCL6 is present throughout the cell fusion process in the fusogenic trophoblastic cell line BeWo. Suppression of BCL6 promotes trophoblast fusion, indicated by enhanced levels of fusion-related β-hCG, syncytin 1 and syncytin 2. Increased mRNA levels of these genes could also be observed in primary term cytotrophoblasts depleted of BCL6. Conversely, stable overexpression of BCL6 reduces the fusion capacity of BeWo cells. These data suggest that an accurately regulated expression of BCL6 is important for proper differentiation and successful syncytialization of trophoblasts. While deregulated BCL6 is linked to lymphomagenesis by blocking lymphocyte terminal differentiation, increased BCL6 in the placenta contributes to the development of preeclampsia by impairing trophoblast differentiation and fusion. KW - BCL6 KW - trophoblast KW - preeclampsia KW - cell fusion KW - differentiation Y1 - 2017 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/32278 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-322783 SN - 1949-2553 N1 - Copyright: Jasmer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. VL - 8 IS - 65 SP - 108643 EP - 108654 PB - Impact Journals LLC CY - [s. l.] ER -