TY  - JOUR
A1  - Benz, Fabian
A1  - Bogen, Andreas
A1  - Praktiknjo, Michael
A1  - Jansen, Christian
A1  - Meyer, Carsten
A1  - Wree, Alexander
A1  - Demir, Münevver
A1  - Loosen, Sven
A1  - Vucur, Mihael
A1  - Schierwagen, Robert
A1  - Tacke, Frank
A1  - Trebicka, Jonel
A1  - Roderburg, Christoph
T1  - Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis
T2  - PLoS one
N2  - Liver cirrhosis represents the common end-stage of chronic liver diseases regardless of its etiology. Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify patients with a higher risk for disease progression and a limited prognosis. SIBLINGs, soluble glycophosphoproteins, are secreted into the blood by immune-cells. While osteopontin, the most prominent member of the SIBLINGs family, has been repeatedly associated with liver cirrhosis, data on the diagnostic and/or prognostic value of bone sialoprotein (BSP) are scarce and partly inconclusive. In this study, we analyzed the diagnostic and prognostic potential of circulating BSP in comparison to other standard laboratory markers in a large cohort of patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS). Serum levels of BSP were similar in patients with different disease stages and were not indicative for prognosis. Interestingly, BSP serum levels did correlate inversely with portal pressure, as well as its surrogates such as platelet count, the portal vein cross-sectional area and correlated positively with the portal venous velocity. In summary, our data highlight that BSP might represent a previously unrecognized marker for portal hypertension in patients with liver cirrhosis.
KW  - Cirrhosis
KW  - Portal veins
KW  - Portal hypertension
KW  - Liver diseases
KW  - Patients
KW  - Veins
KW  - Biomarkers
KW  - Ascites
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54493
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-544937
SN  - 1932-6203
N1  - Copyright: © 2020 Benz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 15
IS  - (4): e0231701
SP  - 1
EP  - 13
PB  - PLoS
CY  - Lawrence, Kan.
ER  -