TY  - JOUR
A1  - Honeder, Clemens
A1  - Engleder, Elisabeth
A1  - Schöpper, Hanna
A1  - Gabor, Franz
A1  - Reznicek, Gottfried
A1  - Wagenblast, Jens
A1  - Gstoettner, Wolfgang
A1  - Arnoldner, Christoph
T1  - Sustained release of triamcinolone acetonide from an intratympanically applied hydrogel designed for the delivery of high glucocorticoid doses
T2  - Audiology & neurotology : basic science and clinical research in the auditory and vestibular system and diseases of the ear
N2  - The pharmacokinetic properties and tolerability of a triamcinolone acetonide poloxamer 407 hydrogel for intratympanic application were investigated in a guinea pig model. Evaluation of in vivo release kinetics showed very high initial perilymph drug levels, with clinically relevant levels present for a minimum of 10 days. Assessment of auditory brainstem response thresholds showed a minimal, delayed and transient threshold shift, which was apparent on day 3 and resolved by day 10. No relevant histological changes of the middle and inner ear structures were noted, and hair cell counts showed no significant differences between treated and untreated ears. Thus, the triamcinolone-acetonide-loaded poloxamer 407 hydrogel is an effective vehicle for sustained high-dose inner ear glucocorticoid delivery.
KW  - Intratympanic drug delivery
KW  - Glucocorticoids
KW  - Triamcinolone acetonide
KW  - Round window membrane
KW  - Inner ear therapy
KW  - Perilymph
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/34391
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-343914
SN  - 1421-9700
SN  - 1420-3030
N1  - This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
VL  - 19
SP  - 193
EP  - 202
PB  - Karger
CY  - Basel
ER  -