TY  - JOUR
A1  - Dongen, Jenny van
A1  - Hagenbeek, Fiona A.
A1  - Suderman, Matthew
A1  - Roetman, Peter J.
A1  - Sugden, Karen
A1  - Geburtig-Chiocchetti, Andreas
A1  - Ismail, Khadeeja
A1  - Mulder, Rosa H.
A1  - Hafferty, Jonathan D.
A1  - Adams, Mark J.
A1  - Walker, Rosie M.
A1  - Morris, Stewart W.
A1  - Lahti, Jari
A1  - Küpers, Leanne K.
A1  - Escaramis, Georgia
A1  - Alemany, Silvia
A1  - Bonder, Marc Jan
A1  - Meijer, Mandy
A1  - Ip, Hill F.
A1  - Jansen, Rick
A1  - Baselmans, Bart M. L.
A1  - Parmar, Priyanka
A1  - Lowry, Estelle
A1  - Streit, Fabian
A1  - Sirignano, Lea
A1  - Send, Tabea S.
A1  - Frank, Josef
A1  - Jylhävä, Juulia
A1  - Wang, Yunzhang
A1  - Mishra, Pashupati Prasad
A1  - Colins, Olivier F.
A1  - Corcoran, David L.
A1  - Poulton, Richie
A1  - Mill, Jonathan
A1  - Hannon, Eilis
A1  - Arseneault, Louise
A1  - Korhonen, Tellervo
A1  - Vuoksimaa, Eero
A1  - Felix, Janine F.
A1  - Bakermans-Kranenburg, Marian J.
A1  - Campbell, Archie
A1  - Czamara, Darina
A1  - Binder, Elisabeth
A1  - Corpeleijn, Eva
A1  - González Ruiz, Juan Ramon
A1  - Grazuleviciene, Regina
A1  - Gutzkow, Kristine B.
A1  - Evandt, Jorunn
A1  - Vafeiadi, Marina
A1  - Klein, Marieke
A1  - Meer, Dennis van der
A1  - Ligthart, Lannie
A1  - Heijmans, Bastiaan Theodoor
A1  - Hoen, Peter A. C. 't
A1  - Meurs, Joyce Berdina Josepha van
A1  - Franke, Lude
A1  - Boomsma, Dorret I.
A1  - Pool, René
A1  - Hottenga, Jouke J.
A1  - Greevenbroek, Marleen M. J. van
A1  - Stehouwer, Coen D. A.
A1  - Kallen, Carla J. H. van der
A1  - Schalkwijk, Casper G.
A1  - Wijmenga, Cisca
A1  - Zhernakova, Sasha
A1  - Tigchelaar, Ettje F.
A1  - Slagboom, P. Eline
A1  - Beekman, Marian
A1  - Deelen, Joris
A1  - Heemst, Diana van
A1  - Veldink, Jan H.
A1  - Berg, Leonard H. van den
A1  - Duijn, Cornelia M. van
A1  - Hofman, Bert A.
A1  - Isaacs, Aaron
A1  - Uitterlinden, André G.
A1  - Jhamai, P. Mila
A1  - Verbiest, Michael
A1  - Suchiman, H. Eka D.
A1  - Verkerk, Marijn
A1  - Breggen, Ruud van der
A1  - Rooij, Jeroen van
A1  - Lakenberg, Nico
A1  - Mei, Hailiang
A1  - Iterson, Maarten van
A1  - Galen, Michiel van
A1  - Bot, Jan
A1  - Zhernakova, Dasha V.
A1  - Hof, Peter van ’t
A1  - Deelen, Patrick
A1  - Nooren, Irene
A1  - Moed, Matthijs
A1  - Vermaat, Martijn
A1  - Luijk, René
A1  - Dijk, Freerk van
A1  - Arindrarto, Wibowo
A1  - Kielbasa, Szymon M.
A1  - Swertz, Morris A.
A1  - Zwet, Erik. W. van
A1  - Hoen, Peter-Bram ’t
A1  - Kluft, Cornelis
A1  - Davies, Gareth E.
A1  - Hakulinen, Christian
A1  - Keltikangas-Järvinen, Liisa
A1  - Franke, Barbara
A1  - Freitag, Christine M.
A1  - Konrad, Kerstin
A1  - Hervás, Amaia
A1  - Fernández-Rivas, Aranzazu
A1  - Vetro, Agnes
A1  - Raitakari, Olli
A1  - Lehtimäki, Terho
A1  - Vermeiren, Robert
A1  - Strandberg, Timo
A1  - Räikkönen, Katri
A1  - Snieder, Harold
A1  - Witt, Stephanie H.
A1  - Deuschle, Michael
A1  - Pedersen, Nancy L.
A1  - Hägg, Sara
A1  - Sunyer, Jordi
A1  - Kaprio, Jaakko
A1  - Ollikainen, Miina
A1  - Moffitt, Terrie E.
A1  - Tiemeier, Henning
A1  - IJzendoorn, Marinus H. van
A1  - Relton, Caroline
A1  - Vrijheid, Martine
A1  - Sebert, Sylvain
A1  - Jarvelin, Marjo-Riitta
A1  - Caspi, Avshalom
A1  - Evans, Kathryn L.
A1  - McIntosh, Andrew M.
A1  - Bartels, Meike
T1  - DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
T2  - Molecular psychiatry
N2  - DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10−7; Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood meta-analysis or in a combined meta-analysis of peripheral blood and cord blood) have been associated with chemical exposures, smoking, cognition, metabolic traits, and genetic variation (mQTLs). Three genes whose expression levels were associated with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On average 44% (range = 3–82%) of the aggression–methylation association was explained by current and former smoking and BMI. These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits.
KW  - Genetics
KW  - Molecular biology
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69301
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-693019
SN  - 1476-5578
N1  - Funding: European Union FP7/2007–2013 ; 602768
VL  - 26
IS  - 6
SP  - 2148
EP  - 2162
PB  - Macmillan
CY  - London
ER  -