TY  - INPR
A1  - Rogala, Sandra
A1  - Ali, Tamer
A1  - Melissari, Maria-Theodora
A1  - Währisch, Sandra
A1  - Schuster, Peggy
A1  - Sarre, Alexandre
A1  - Böttger, Thomas
A1  - Rogg, Eva-Maria Pia
A1  - Kaur, Jaskiran
A1  - Krishnan, Jaya
A1  - Dimmeler, Stefanie
A1  - Ounzain, Samir
A1  - Pedrazzini, Thierry
A1  - Herrmann, Bernhard
A1  - Grote, Phillip
T1  - The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury
T2  - bioRxiv
N2  - After myocardial infarction in the adult heart the remaining, non-infarcted tissue adapts to compensate the loss of functional tissue. This adaptation requires changes in gene expression networks, which are mostly controlled by transcription regulating proteins. Long non-coding transcripts (lncRNAs) are now recognized for taking part in fine-tuning such gene programs. We identified and characterized the cardiomyocyte specific lncRNA Sweetheart RNA (Swhtr), an approximately 10 kb long transcript divergently expressed from the cardiac core transcription factor coding gene Nkx2-5. We show that Swhtr is dispensable for normal heart development and function, but becomes essential for the tissue adaptation process after myocardial infarction. Re-expressing Swhtr from an exogenous locus rescues the Swhtr null phenotype. Genes depending on Swhtr after cardiac stress are significantly occupied, and therefore most likely regulated by NKX2-5. Our results indicate a synergistic role for Swhtr and the developmentally essential transcription factor NKX2-5 in tissue adaptation after myocardial injury.
KW  - LncRNA
KW  - Nkx2-5
KW  - hypertrophy
KW  - trans
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73123
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-731231
UR  - https://www.biorxiv.org/content/10.1101/2022.11.14.516395v1
N1  - Now published in Nature Communications doi: 10.1038/s41467-023-42760-y
IS  - 2022.11.14.516395 Version 1
PB  - bioRxiv
ER  -