TY  - JOUR
A1  - Tillein, Jochen
A1  - Heid, Silvia
A1  - Lang, Elisabeth
A1  - Hartmann, Rainer
A1  - Kral, Andrej
T1  - Development of brainstem-evoked responses in congenital auditory deprivation
T2  - Neural plasticity
N2  - To compare the development of the auditory system in hearing and completely acoustically deprived animals, naive congenitally deaf white cats (CDCs) and hearing controls (HCs) were investigated at different developmental stages from birth till adulthood. The CDCs had no hearing experience before the acute experiment. In both groups of animals, responses to cochlear implant stimulation were acutely assessed. Electrically evoked auditory brainstem responses (E-ABRs) were recorded with monopolar stimulation at different current levels. CDCs demonstrated extensive development of E-ABRs, from first signs of responses at postnatal (p.n.) day 3 through appearance of all waves of brainstem response at day 8 p.n. to mature responses around day 90 p.n.. Wave I of E-ABRs could not be distinguished from the artifact in majority of CDCs, whereas in HCs, it was clearly separated from the stimulus artifact. Waves II, III, and IV demonstrated higher thresholds in CDCs, whereas this difference was not found for wave V. Amplitudes of wave III were significantly higher in HCs, whereas wave V amplitudes were significantly higher in CDCs. No differences in latencies were observed between the animal groups. These data demonstrate significant postnatal subcortical development in absence of hearing, and also divergent effects of deafness on early waves II–IV and wave V of the E-ABR.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26767
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-267673
SN  - 2090-5904
SN  - 0792-8483
SN  - 1687-5443
N1  - Copyright © 2012 J. Tillein et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
N1  - Erratum s.a. urn:nbn:de:hebis:30:3-278501
VL  - 2012
IS  - Article ID 182767
PB  - Hindawi
CY  - New York, NY
ER  -