TY  - JOUR
A1  - Tsaur, Igor
A1  - Noack, Anika
A1  - Makarević, Jasmina
A1  - Oppermann, Elsie
A1  - Waaga, Ana Maria da Silva Rosa
A1  - Gasser, Martin
A1  - Borgmann, Hendrik
A1  - Huesch, Tanja
A1  - Gust, Kilian
A1  - Reiter, Michael Andreas
A1  - Schilling, David
A1  - Bartsch, Georg
A1  - Haferkamp, Axel
A1  - Blaheta, Roman A.
T1  - CCL2 chemokine as a potential biomarker for prostate cancer : a pilot study
T2  - Cancer research and treatment
N2  - Purpose: Prostate specific antigen is not reliable in diagnosing prostate cancer (PCa), making the identification of novel, precise diagnostic biomarkers important. Since chemokines are associated with more aggressive disease and poor prognosis in diverse malignancies, we aimed to investigate the diagnostic relevance of chemokines in PCa.
Materials and methods: Preoperative and early postoperative serum samples were obtained from 39 consecutive PCa patients undergoing radical prostatectomy. Serum from 15 healthy volunteers served as controls. Concentrations of CXCL12, CXCL13, CX3CL1, CCL2, CCL5, and CCL20 were measured in serum by Luminex. The expression activity of CXCR3, CXCR4, CXCR5, CXCR7, CXCL12, CXCL13, CX3CR1, CXCL1, CCR2, CCR5, CCR6, CCR7, CCL2, and CCL5 mRNA was assessed in tumor and adjacent normal tissue of prostatectomy specimens by quantitative real-time polymerase chain reaction. The associations of these chemokines with clinical and histological parameters were tested.
Results: The gene expression activity of CCL2 and CCR6 was significantly higher in tumor tissue compared to adjacent normal tissue. CCL2 was also significantly higher in the blood samples of PCa patients, compared to controls. CCL5, CCL20, and CX3CL1 were lower in patient serum, compared to controls. CCR2 tissue mRNA was negatively correlated with the Gleason score and grading.
Conclusion: Chemokines are significantly modified during tumorigenesis of PCa, and CCL2 is a promising diagnostic biomarker.
KW  - Prostatic neoplasms
KW  - Diagnosis
KW  - Biological markers
KW  - Chemokines
KW  - Chemokine CCL2
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/37363
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-373639
SN  - 2005-9256
SN  - 1598-2998
N1  - Copyright © 2015 by the Korean Cancer Association. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/)which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 47
IS  - 2
SP  - 306
EP  - 312
PB  - Korean Cancer Association
CY  - Seoul
ER  -