TY  - JOUR
A1  - Maronde, Erik
T1  - Cyclic nucleotide (cNMP) analogues: past, present and future
T2  - International journal of molecular sciences
N2  - Cyclic nucleotides are important second messengers involved in cellular events, and analogues of this type of molecules are promising drug candidates. Some cyclic nucleotide analogues have become standard tools for the investigation of biochemical and physiological signal transduction pathways, such as the Rp-diastereomers of adenosine and guanosine 3′,5′-cyclic monophosphorothioate, which are competitive inhibitors of cAMP- and cGMP-dependent protein kinases. Next generation analogues exhibit a higher membrane permeability, increased resistance against degradation, and improved target specificity, or are caged or photoactivatable for fast and/or targeted cellular imaging. Novel specific nucleotide analogues activating or inhibiting cyclic nucleotide-dependent ion channels, EPAC/GEF proteins, and bacterial target molecules have been developed, opening new avenues for basic and applied research. This review provides an overview of the current state of the field, what can be expected in the future and some practical considerations for the use of cyclic nucleotide analogues in biological systems.
KW  - cyclic nucleotide analogues
KW  - cAMP
KW  - cGMP
KW  - 2′,3′-cGAMP
KW  - cyclic nucleotide binding proteins
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/81475
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-814754
SN  - 1422-0067
N1  - This work was supported by basic funding by the Senckenbergische Anatomie, Medical Faculty of the Goethe University, Frankfurt, Germany.
VL  - 22
IS  - 23, art. 12879
SP  - 1
EP  - 11
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -