TY - JOUR A1 - D’Angelo, Tommaso A1 - Albrecht, Moritz Hans Ernst A1 - Caudo, Danilo A1 - Mazziotti, Silvio A1 - Vogl, Thomas J. A1 - Wichmann, Julian A1 - Martin, Simon A1 - Yel, Ibrahim A1 - Ascenti, Giorgio A1 - Koch, Vitali A1 - Cicero, Giuseppe A1 - Blandino, Alfredo A1 - Booz, Christian T1 - Virtual non-calcium dual-energy CT: clinical applications T2 - European radiology experimental N2 - Dual-energy CT (DECT) has emerged into clinical routine as an imaging technique with unique postprocessing utilities that improve the evaluation of different body areas. The virtual non-calcium (VNCa) reconstruction algorithm has shown beneficial effects on the depiction of bone marrow pathologies such as bone marrow edema. Its main advantage is the ability to substantially increase the image contrast of structures that are usually covered with calcium mineral, such as calcified vessels or bone marrow, and to depict a large number of traumatic, inflammatory, infiltrative, and degenerative disorders affecting either the spine or the appendicular skeleton. Therefore, VNCa imaging represents another step forward for DECT to image conditions and disorders that usually require the use of more expensive and time-consuming techniques such as magnetic resonance imaging, positron emission tomography/CT, or bone scintigraphy. The aim of this review article is to explain the technical background of VNCa imaging, showcase its applicability in the different body regions, and provide an updated outlook on the clinical impact of this technique, which goes beyond the sole improvement in image quality. KW - Algorithms KW - Bone marrow KW - Calcium KW - Edema KW - Tomography (x-ray computed) Y1 - 2021 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63605 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-636057 SN - 2509-9280 N1 - Open Access funding enabled and organized by Projekt DEAL. VL - 5 IS - art. 38 SP - 1 EP - 13 PB - Springer International Publishing CY - [Cham] ER -