TY  - JOUR
A1  - Delbrück, Marla
A1  - Hoehl, Sebastian
A1  - Toptan, Tuna
A1  - Schenk, Barbara
A1  - Grikscheit, Katharina
A1  - Metzler, Melinda
A1  - Herrmann, Eva
A1  - Ciesek, Sandra
T1  - Low but recoverable markers of humoral immune response to BNT162b2 in elderly LTCF residents five to seven months after two-dose vaccination
T2  - Frontiers in aging
N2  - The immune response is known to wane after vaccination with BNT162b2, but the role of age, morbidity and body composition is not well understood. We conducted a cross-sectional study in long-term care facilities (LTCFs) for the elderly. All study participants had completed two-dose vaccination with BNT162b2 five to 7 months before sample collection. In 298 residents (median age 86 years, range 75–101), anti-SARS-CoV-2 rector binding IgG antibody (anti-RBD-IgG) concentrations were low and inversely correlated with age (mean 51.60 BAU/ml). We compared the results to Health Care Workers (HCW) aged 18–70 years (n = 114, median age: 53 years), who had a higher mean anti-RBD-IgG concentration of 156.99 BAU/ml. Neutralization against the Delta variant was low in both groups (9.5% in LTCF residents and 31.6% in HCWs). The Charlson Comorbidity Index was inversely correlated with anti-RBD-IgG, but not the body mass index (BMI). A control group of 14 LTCF residents with known breakthrough infection had significant higher antibody concentrations (mean 3,199.65 BAU/ml), and 85.7% had detectable neutralization against the Delta variant. Our results demonstrate low but recoverable markers of immunity in LTCF residents five to 7 months after vaccination.
KW  - COVID-19
KW  - SARS-CoV-2
KW  - elderly
KW  - immunity
KW  - immunosenescence
KW  - multimorbidity
KW  - vaccination
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/81397
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-813976
SN  - 2673-6217
N1  - This study was funded by the Hessian Ministry of Social Issues and Integration.
VL  - 3
IS  - art. 883724
SP  - 1
EP  - 7
PB  - Frontiers Media S.A.
CY  - Lausanne
ER  -