TY  - JOUR
A1  - Dreßler, Melanie
A1  - Fußbroich, Daniela
A1  - Böhler, Lisa
A1  - Herrmann, Eva
A1  - Benker, Nicole
A1  - Tytyk, Markus
A1  - Schulze, Johannes B.
A1  - Schubert, Ralf
A1  - Beermann, Christopher
A1  - Zielen, Stefan
T1  - Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial
T2  - Lipids in health and disease
N2  - Background: Many patients suffering from exercise-induced asthma (EIA) have normal lung function at rest and show symptoms and a decline in FEV1 when they do sports or during exercise-challenge. It has been described that long-chain polyunsaturated fatty acids (LCPUFA) could exert a protective effect on EIA.
Methods: In this study the protective effect of supplementation with a special combination of n-3 and n-6 LCPUFA (sc-LCPUFA) (total 1.19 g/ day) were investigated in an EIA cold air provocation model. Primary outcome measure: Decrease in FEV1 after exercise challenge and secondary outcome measure: anti-inflammatory effects monitored by exhaled NO (eNO) before and after sc-LCPUFA supplementation versus placebo.
Results: Ninety-nine patients with exercise-induced symptoms aged 10 to 45 were screened by a standardized exercise challenge in a cold air chamber at 4 °C. Seventy-three patients fulfilled the inclusion criteria of a FEV1 decrease > 15% and were treated double-blind placebo-controlled for 4 weeks either with sc-LCPUFA or placebo. Thirty-two patients in each group completed the study. Mean FEV1 decrease after cold air exercise challenge and eNO were unchanged after 4 weeks sc-LCPUFA supplementation.
Conclusion: Supplementation with sc-LCPUFA at a dose of 1.19 g/d did not have any broncho-protective and anti-inflammatory effects on EIA.
Trial registration: Clinical trial registration number: NCT02410096. Registered 7 February 2015 at Clinicaltrial.gov
KW  - Exercise-induced asthma
KW  - Exercise challenge
KW  - Forced expiratory volume in 1 s
KW  - Exhaled nitric oxide
KW  - Longchain polyunsaturated fatty acids
KW  - Double-blind placebo-controlled trial
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/55499
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-554991
SN  - 1476-511X
N1  - © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License,
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VL  - 19
IS  - art. 167
SP  - 1
EP  - 10
PB  - Biomed Central
CY  - London
ER  -