TY  - JOUR
A1  - Kreis, Nina-Naomi
A1  - Friemel, Alexandra
A1  - Zimmer, Brigitte
A1  - Roth, Susanne
A1  - Rieger, Michael A.
A1  - Rolle, Udo
A1  - Louwen, Frank
A1  - Yuan, Juping
T1  - Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation
T2  - Oncotarget
N2  - The multifunctional protein p21Cip1/CDKN1A (p21) is an important and universal Cdk-interacting protein. Recently, we have reported that p21 is involved in the regulation of the mitotic kinase Cdk1/cyclin B1 and critical for successful mitosis and cytokinesis. In the present work we show that S130 of p21 is phosphorylated by Cdk1/cyclin B1 during mitosis, which reduces p21’s stability and binding affinity to Cdk1/cyclin B1. Interfering with this phosphorylation results in extended mitotic duration and defective chromosome segregation, indicating that this regulation ensures proper mitotic progression. Given that p53, the major transcriptional activator of p21, is the most frequently mutated gene in human cancer and that deregulated Cdk1 associates with the development of different types of cancer, this work provides new insight into the understanding of how deregulated p21 contributes to chromosomal instability and oncogenesis.
KW  - p21 phosphorylation
KW  - mitosis
KW  - Cdk1/cyclin B1
KW  - p21 stability
KW  - chromosome segregation
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45839
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-458394
SN  - 1949-2553
N1  - All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
VL  - 7
IS  - 31
SP  - 50215
EP  - 50228
PB  - Impact Journals LLC
CY  - [s. l.]
ER  -