TY  - JOUR
A1  - Farassat, Navid
A1  - Machado Costa, Kauê
A1  - Stojanovic, Strahinja
A1  - Albert, Stefan
A1  - Kovacheva, Lora
A1  - Shin, Josef
A1  - Egger, Richard
A1  - Somayaji, Mahalakshmi
A1  - Duvarci, Sevil
A1  - Schneider, Gaby
A1  - Roeper, Jochen
T1  - In vivo functional diversity of midbrain dopamine neurons within identified axonal projections
T2  - eLife
N2  - Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from differences in intrinsic properties and connectivity to selective task engagement in behaving animals. Distinct in vitro biophysical features of DA neurons have been associated with different axonal projection targets. However, it is unknown how this translates to different firing patterns of projection-defined DA subpopulations in the intact brain. We combined retrograde tracing with single-unit recording and labelling in mouse brain to create an in vivo functional topography of the midbrain DA system. We identified differences in burst firing among DA neurons projecting to dorsolateral striatum. Bursting also differentiated DA neurons in the medial substantia nigra (SN) projecting either to dorsal or ventral striatum. We found differences in mean firing rates and pause durations among ventral tegmental area (VTA) DA neurons projecting to lateral or medial shell of nucleus accumbens. Our data establishes a high-resolution functional in vivo landscape of midbrain DA neurons.
KW  - Research article
KW  - Neuroscience
KW  - Mouse
KW  - Dopamine
KW  - Axon
KW  - Striatum
KW  - Action potential
KW  - Burst
KW  - Pause
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51097
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-510974
SN  - 2050-084X
N1  - This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication
VL  - 8
IS  - e48408
SP  - 1
EP  - 27
PB  - eLife Sciences Publications
CY  - Cambridge
ER  -