TY  - JOUR
A1  - Groß, Tilman
A1  - Wack, Gesine
A1  - Syhr, Katharina Martina Janice
A1  - Tolmachova, Tanya
A1  - Seabra, Miguel C.
A1  - Geisslinger, Gerd
A1  - Niederberger, Ellen
A1  - Schmidtko, Achim
A1  - Kallenborn-Gerhardt, Wiebke
T1  - Rab27a contributes to the processing of inflammatory pain in mice
T2  - Cells
N2  - Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that is associated with great impairment of quality of life. An increasing body of evidence indicates that members of the Rab family of small GTPases contribute to pain processing; however, their specific functions remain poorly understood. Here, we found using immunofluorescence staining and in situ hybridization that the small GTPase Rab27a is highly expressed in sensory neurons and in the superficial dorsal horn of the spinal cord of mice. Rab27a mutant mice, which carry a single-nucleotide missense mutation of Rab27a leading to the expression of a nonfunctional protein, show reduced mechanical hyperalgesia and spontaneous pain behavior in inflammatory pain models, while their responses to acute noxious mechanical and thermal stimuli is not affected. Our study uncovers a previously unrecognized function of Rab27a in the processing of persistent inflammatory pain in mice.
KW  - Rab27a
KW  - inflammatory pain
KW  - spinal cord
KW  - dorsal root ganglia
KW  - mice
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/55439
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-554390
SN  - 2073-4409
N1  - © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
VL  - 9
IS  - 6, art. 1488
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel
ER  -