TY  - JOUR
A1  - Zepf, Florian Daniel
A1  - Sungurtekin, Idil
A1  - Glass, Franziska
A1  - Elstrodt, Linda
A1  - Peetz, Dirk
A1  - Hintereder, Gudrun
A1  - Kratzsch, Jürgen
A1  - Biskup, Caroline Sarah
A1  - Poustka, Fritz
A1  - Wöckel, Lars
T1  - Differences in zinc status and the leptin axis in anorexic and recovered adolescents and young adults : a pilot study
T2  - Food & nutrition research
N2  - Background: Evidence from animal studies suggests that leptin metabolism is associated with zinc (Zn) status. However, research investigating this relationship in adolescents and young adults with anorexia nervosa (AN) is scarce; the present study aims to fill that gap.
Methods: Serum concentrations of leptin, the soluble leptin receptor (sOB-R) and the free leptin index (FLI) were obtained in healthy control subjects (n=19), acutely ill individuals (n=14) and recovered patients with AN (n=15). Serum Zn concentrations noted in previous research data were also incorporated for all groups.
Results: Leptin, FLI and Zn concentrations were higher in recovered subjects with AN when compared with acutely ill AN patients. Remitted patients showed higher sOB-R concentrations but no difference in FLI compared with the control group. Leptin and FLI were lower in the acutely ill patients compared with the control subjects, who showed no differences in Zn concentrations. Zn concentrations were not correlated with leptin, sOB-R or FLI concentrations in any of the three investigated subgroups.
Conclusions: The present investigation does not entirely support an association between Zn, Leptin and FLI concentrations in subjects with AN, possibly due to limited statistical power. Further research and replication of the present findings related to the interaction between leptin and Zn is warranted. However, with respect to serum leptin levels the data of the present investigation indicate that acutely ill and remitted patients with AN differ as regards serum leptin concentrations and FLI, which is in line with previous research.
KW  - anorexia nervosa
KW  - leptin, leptin receptor (sOB-R)
KW  - free leptin index (FLI)
KW  - zinc
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26682
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-266825
SN  - 1654-661X
SN  - 1654-6628
N1  - Copyright © 2012 F.D. Zepf et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 56
IS  - 10941
PB  - Co-Action Publishing
CY  - Häggeby [u.a.]
ER  -