TY  - JOUR
A1  - Tomaskovic, Ines
A1  - González, Alexis
A1  - Đikić, Ivan
T1  - Ubiquitin and Legionella: From bench to bedside
T2  - Seminars in Cell & Developmental Biology
N2  - Legionella pneumophila, a Gram-negative intracellular bacterium, is one of the major causes of Legionnaires’ disease, a specific type of atypical pneumonia. Despite intensive research efforts that elucidated many relevant structural, molecular and medical insights into Legionella’s pathogenicity, Legionnaires’ disease continues to present an ongoing public health concern. Legionella’s virulence is based on its ability to simultaneously hijack multiple molecular pathways of the host cell to ensure its fast replication and dissemination. Legionella usurps the host ubiquitin system through multiple effector proteins, using the advantage of both conventional and unconventional (phosphoribosyl-linked) ubiquitination, thus providing optimal conditions for its replication. In this review, we summarize the current understanding of L. pneumophila from medical, biochemical and molecular perspectives. We describe the clinical disease presentation, its diagnostics and treatment, as well as host-pathogen interactions, with the emphasis on the ability of Legionella to target the host ubiquitin system upon infection. Furthermore, the interdisciplinary use of innovative technologies enables better insights into the pathogenesis of Legionnaires’ disease and provides new opportunities for its treatment and prevention.
KW  - Legionella pneumophila
KW  - Conventional and unconventional ubiquitination
KW  - Autophagy
KW  - novel technologies
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78312
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-783125
SN  - 1084-9521
VL  - 132
SP  - 230
EP  - 241
PB  - Elsevier
CY  - Amsterdam
ER  -