TY - JOUR A1 - Wei, Wu A1 - Wheeler, Diek W. A1 - Pipa, Gordon T1 - Bivariate and multivariate NeuroXidence : a robust and reliable method to detect modulations of spike ; spike synchronization across experimental conditions T2 - Frontiers in neuroinformatics N2 - Synchronous neuronal firing has been proposed as a potential neuronal code. To determine whether synchronous firing is really involved in different forms of information processing, one needs to directly compare the amount of synchronous firing due to various factors, such as different experimental or behavioral conditions. In order to address this issue, we present an extended version of the previously published method, NeuroXidence. The improved method incorporates bi- and multivariate testing to determine whether different factors result in synchronous firing occurring above the chance level. We demonstrate through the use of simulated data sets that bi- and multivariate NeuroXidence reliably and robustly detects joint-spike-events across different factors. KW - synchronous firing KW - factor KW - modulation of synchrony KW - joint-spike-event KW - bivariate KW - multivariate KW - NeuroXidence Y1 - 2011 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/29308 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-293080 SN - 1662-5196 N1 - Copyright: © 2011 Wu, Wheeler and Pipa. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. VL - 5 IS - Art. 14 SP - 1 EP - 11 PB - Frontiers Research Foundation CY - Lausanne ER -