TY  - JOUR
A1  - Rogers, Jack C.
A1  - Gonzalez-Madruga, Karen
A1  - Kohls, Gregor
A1  - Baker, Rosalind
A1  - Clanton, Roberta
A1  - Pauli, Ruth
A1  - Birch, Philippa
A1  - Chowdhury, Alimul I.
A1  - Kirchner, Marietta
A1  - Andersson, Jesper
A1  - Smaragdi, Areti
A1  - Puzzo, Ignazio
A1  - Baumann, Sarah
A1  - Raschle, Nora Maria
A1  - Fehlbaum, Lynn Valérie
A1  - Menks, Willeke M.
A1  - Steppan, Martin
A1  - Stadler, Christina
A1  - Konrad, Kerstin
A1  - Freitag, Christine M.
A1  - Fairchild, Graeme
A1  - De Brito, Stéphane A.
T1  - White matter microstructure in youths with conduct disorder : effects of sex and variation in callous traits
T2  - Journal of the American Academy of Child and Adolescent Psychiatry
N2  - Objective: Studies using diffusion tensor imaging (DTI) to investigate white matter (WM) microstructure in youths with conduct disorder (CD) have reported disparate findings. We investigated WM alterations in a large sample of youths with CD, and examined the influence of sex and callous-unemotional (CU) traits.
Method: DTI data were acquired from 124 youths with CD (59 female) and 174 typically developing (TD) youths (103 female) 9 to 18 years of age. Tract-based spatial statistics tested for effects of diagnosis and sex-by-diagnosis interactions. Associations with CD symptoms, CU traits, a task measuring impulsivity, and the impact of comorbidity, and age- and puberty-related effects were examined.
Results: Youths with CD exhibited higher axial diffusivity in the corpus callosum and lower radial diffusivity and mean diffusivity in the anterior thalamic radiation relative to TD youths. Female and male youths with CD exhibited opposite changes within the internal capsule, fornix, posterior thalamic radiation, and uncinate fasciculus. Within the CD group, CD symptoms and callous traits exerted opposing influences on corpus callosum axial diffusivity, with callous traits identified as the unique clinical feature predicting higher axial diffusivity and lower radial diffusivity within the corpus callosum and anterior thalamic radiation, respectively. In an exploratory analysis, corpus callosum axial diffusivity partially mediated the association between callous traits and impulsive responses to emotional faces. Results were not influenced by symptoms of comorbid disorders, and no age- or puberty-related interactions were observed.
Conclusion: WM alterations within the corpus callosum represent a reliable neuroimaging marker of CD. Sex and callous traits are important factors to consider when examining WM in CD.
KW  - conduct disorder
KW  - callous-unemotional traits
KW  - diffusion tensor imaging (DTI)
KW  - sex differences
KW  - FemNAT-CD
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50071
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-500710
SN  - 1527-5418
SN  - 0890-8567
N1  - © 2019 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 58
IS  - 12
SP  - 1184
EP  - 1196
PB  - Elsevier ; ScienceDirect ; Ovid
CY  - Kidlington [u. a.] ; Amsterdam [u. a.] ; [s. l.]
ER  -