TY  - JOUR
A1  - Drewry, David H.
A1  - Wells, Carrow I.
A1  - Andrews, David M.
A1  - Angell, Richard
A1  - Al-Ali, Hassan
A1  - Axtman, Alison D.
A1  - Capuzz, Stephen J.
A1  - Elkins, Jonathan M.
A1  - Ettmayer, Peter
A1  - Frederiksen, Mathias
A1  - Gileadi, Opher
A1  - Gray, Nathanael S.
A1  - Hooper, Alice
A1  - Knapp, Stefan
A1  - Laufer, Stefan
A1  - Lücking, Ulrich
A1  - Michaelides, Michael
A1  - Müller, Susanne
A1  - Muratov, Eugene
A1  - Denny, R. Aldrin
A1  - Saikatendu, Kumar S.
A1  - Treiber, Daniel K.
A1  - Zuercher, William J.
A1  - Willson, Timothy M.
T1  - Progress towards a public chemogenomic set for protein kinases and a call for contributions
T2  - PLoS one
N2  - Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases.
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43982
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-439825
SN  - 1932-6203
N1  - Copyright: © 2017 Drewry et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 12
IS  - (8): e0181585
SP  - 1
EP  - 20
PB  - PLoS
CY  - Lawrence, Kan.
ER  -