TY  - JOUR
A1  - Lauenstein, Hans-Dieter
A1  - Quarcoo, David
A1  - Welte, Tobias
A1  - Braun, Armin
A1  - Groneberg, Jan David Alexander
T1  - Expression of VPAC1 in a murine model of allergic asthma
T2  - Journal of occupational medicine and toxicology
N2  - Vasoactive intestinal polypeptide (VIP) is a putative neurotransmitter of the inhibitory non-adrenergic non-cholinergic nervous system and influences the mammalian airway function in various ways. Hence known for bronchodilatory, immunomodulatory and mucus secretion modulating effects by interacting with the VIP receptors VPAC1 and VPAC2, it is discussed to be a promising target for pharmaceutical intervention in common diseases such as COPD and bronchial asthma. Here we examined the expression and transcriptional regulation of VPAC1 in the lungs of allergic mice using an ovalbumin (OVA) -induced model of allergic asthma. Mice were sensitized to OVA and challenged with an OVA aerosol. In parallel a control group was sham sensitized with saline. VPAC1 expression was examined using RT-PCR and real time-PCR studies were performed to quantify gene transcription. VPAC1 mRNA expression was detected in all samples of OVA-sensitized and challenged animals and control tissues. Further realtime analysis did not show significant differences at the transcriptional level.
Although the present studies did not indicate a major transcriptional regulation of VPAC1 in states of allergic airway inflammation, immunomodulatory effects of VPAC1 might still be present due to regulations at the translational level.
KW  - VIP
KW  - VPAC1
KW  - Neurotransmitter
KW  - Asthma
KW  - Allergy
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/32413
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-324130
SN  - 1745-6673
N1  - © 2013 Lauenstein et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 8
IS  - 28
PB  - BioMed Central
CY  - London
ER  -