TY  - JOUR
A1  - Kolodziej, Stephan
A1  - Lausen, Olga Nikolaevna
A1  - Oellerich, Thomas
A1  - Herglotz, Julia
A1  - Backert, Ingo
A1  - Kohrs, Nicole
A1  - Buscató Arsequell, Estella
A1  - Wittmann, Sandra Kerstin
A1  - Salinas-Riester, Gabriela
A1  - Bönig, Halvard-Björn
A1  - Karas, Michael
A1  - Serve, Hubert
A1  - Proschak, Ewgenij
A1  - Lausen, Jörn
T1  - PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation
T2  - Nature Communications
N2  - The transcription factor Tal1 is a critical activator or repressor of gene expression in hematopoiesis and leukaemia. The mechanism by which Tal1 differentially influences transcription of distinct genes is not fully understood. Here we show that Tal1 interacts with the peptidylarginine deiminase IV (PADI4). We demonstrate that PADI4 can act as an epigenetic coactivator through influencing H3R2me2a. At the Tal1/PADI4 target gene IL6ST the repressive H3R2me2a mark triggered by PRMT6 is counteracted by PADI4, which augments the active H3K4me3 mark and thus increases IL6ST expression. In contrast, at the CTCF promoter PADI4 acts as a repressor. We propose that the influence of PADI4 on IL6ST transcription plays a role in the control of IL6ST expression during lineage differentiation of hematopoietic stem/progenitor cells. These results open the possibility to pharmacologically influence Tal1 in leukaemia.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/37390
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-373900
SN  - 2041-1723
N1  - This work is licensed under a Creative Commons Attribution- NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons. org/licenses/by-nc-nd/3.0/
VL  - 5
IS  - 3995
SP  - 1
EP  - 12
PB  - Nature Publishing Group
CY  - London
ER  -