TY  - JOUR
A1  - Grün, J. Tassilo
A1  - Schwalbe, Harald
T1  - Folding dynamics of polymorphic G-quadruplex structures
T2  - Biopolymers
N2  - G-quadruplexes (G4), found in numerous places within the human genome, are involved in essential processes of cell regulation. Chromosomal DNA G4s are involved for example, in replication and transcription as first steps of gene expression. Hence, they influence a plethora of downstream processes. G4s possess an intricate structure that differs from canonical B-form DNA. Identical DNA G4 sequences can adopt multiple long-lived conformations, a phenomenon known as G4 polymorphism. A detailed understanding of the molecular mechanisms that drive G4 folding is essential to understand their ambivalent regulatory roles. Disentangling the inherent dynamic and polymorphic nature of G4 structures thus is key to unravel their biological functions and make them amenable as molecular targets in novel therapeutic approaches. We here review recent experimental approaches to monitor G4 folding and discuss structural aspects for possible folding pathways. Substantial progress in the understanding of G4 folding within the recent years now allows drawing comprehensive models of the complex folding energy landscape of G4s that we herein evaluate based on computational and experimental evidence.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/74441
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-744418
SN  - 1097-0282
N1  - Funding information: Deutsche Forschungsgemeinschaft; Hessisches Ministerium für Wissenschaft und Kunst; Council for Higher Education & Israel Academy of Sciences and Humanities Open access funding enabled and organized by Projekt DEAL.
N1  - This work was further supported by the Deutsche Forschungsgemeinschaft (DFG) through GRK1986 “CLiC”.
VL  - 113
IS  - 1, art. e23477
SP  - 1
EP  - 15
PB  - Wiley
CY  - New York, NY
ER  -