TY  - JOUR
A1  - Porfirio Xavier, Pedro Luiz
A1  - Müller, Susanne
A1  - Fukumasu, Heidge
T1  - Epigenetic mechanisms in canine cancer
T2  - Frontiers in oncology
N2  - A plethora of data has highlighted the role of epigenetics in the development of cancer. Initiation and progression of different cancer types are associated with a variety of changes of epigenetic mechanisms, including aberrant DNA methylation, histone modifications, and miRNA expression. At the same time, advances in the available epigenetic tools allow to investigate and reverse these epigenetic changes and form the basis for the development of anticancer drugs in human oncology. Although human and canine cancer shares several common features, only recently that studies emerged investigating the epigenetic landscape in canine cancer and applying epigenetic modulators to canine cancer. This review focuses on the existing studies involving epigenetic changes in different types of canine cancer and the use of small-molecule inhibitors in canine cancer cells.
KW  - comparative oncology
KW  - epigenetics
KW  - DNA methylation
KW  - histone modifications
KW  - canine cancer
KW  - non-coding RNAs
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57018
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-570187
SN  - 2234-943X
VL  - 10
IS  - 591843
PB  - Frontiers Media
CY  - Lausanne
ER  -