TY  - JOUR
A1  - Lafon, Belen
A1  - Henin, Simon
A1  - Huang, Yu
A1  - Friedman, Daniel
A1  - Melloni, Lucia
A1  - Thesen, Thomas
A1  - Doyle, Werner
A1  - Buzsáki, György
A1  - Devinsky, Orrin
A1  - Parra, Lucas Cristobal
A1  - Liu, Anli
T1  - Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings
T2  - Nature Communications
N2  - Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current stimulation (tACS) can entrain and enhance neural rhythms related to memory, but the evidence from non-invasive recordings has remained inconclusive. Here, we measure endogenous spindle and theta activity intracranially in humans during low-frequency tACS and find no stable entrainment of spindle power during non-REM sleep, nor of theta power during resting wakefulness. As positive controls, we find robust entrainment of spindle activity to endogenous slow-wave activity in 66% of electrodes as well as entrainment to rhythmic noise-burst acoustic stimulation in 14% of electrodes. We conclude that low-frequency tACS at common stimulation intensities neither acutely modulates spindle activity during sleep nor theta activity during waking rest, likely because of the attenuated electrical fields reaching the cortical surface.
KW  - Consolidation
KW  - Electroencephalography – EEG
KW  - EpilepsyNon-REM sleep
KW  - Non-REM sleep
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48371
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-483717
SN  - 2041-1723
N1  - Rights and permissions: Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
N1  - Erratum erschienen in: Nature Communications, 9.2018, Nr. 1, Art. 949, doi:10.1038/s41467-018-03392-9
VL  - 8
IS  - 1, Art. 1199
SP  - 1
EP  - 14
PB  - Nature Publishing Group UK
CY  - [London]
ER  -