TY  - JOUR
A1  - Hiß, Jan Alexander
A1  - Schneider, Gisbert
T1  - Domain organization of long autotransporter signal sequences
T2  - Bioinformatics and Biology Insights
N2  - Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane. They often possess exceptionally long N-terminal signal sequences. We analyzed 90 long signal sequences of bacterial autotransporters and members of the two-partner secretion pathway in silico and describe common domain organization found in 79 of these sequences. The domains are in agreement with previously published experimental data. Our algorithmic approach allows for the systematic identification of functionally different domains in long signal sequences. Keywords: bacterial autotransporter, sequence analysis, pattern, protein targeting, signal peptide, protein trafficking
KW  - bacterial autotransporter
KW  - sequence analysis
KW  - pattern
KW  - protein targeting
KW  - signal peptide
KW  - protein trafficking
Y1  - 2009
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/20011
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-82650
N1  - This article is available from http://www.la-press.com. © the authors, licensee Libertas Academica Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction provided the original work is properly cited.
VL  - 3
SP  - 189
EP  - 204
ER  -