TY  - JOUR
A1  - Christen, Urs
A1  - Hintermann, Edith
T1  - Immunopathogenic mechanisms of autoimmune Hepatitis : how much do we know from animal models?
T2  - International journal of molecular sciences
N2  - Autoimmune hepatitis (AIH) is characterized by a progressive destruction of the liver parenchyma and a chronic fibrosis. The current treatment of autoimmune hepatitis is still largely dependent on the administration of corticosteroids and cytostatic drugs. For a long time the development of novel therapeutic strategies has been hampered by a lack of understanding the basic immunopathogenic mechanisms of AIH and the absence of valid animal models. However, in the past decade, knowledge from clinical observations in AIH patients and the development of innovative animal models have led to a situation where critical factors driving the disease have been identified and alternative treatments are being evaluated. Here we will review the insight on the immunopathogenesis of AIH as gained from clinical observation and from animal models.
KW  - AIH immunopathogenesis
KW  - autoantibodies
KW  - T cells
KW  - cytokines
KW  - chemokines: CYP2D6 model
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/44117
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-441172
SN  - 1422-0067
SN  - 1661-6596
N1  - © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
VL  - 17
IS  - 12, Art. 2007
SP  - 1
EP  - 19
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -