TY  - JOUR
A1  - Weber, Sarah
A1  - Parmon, Anastasia
A1  - Kurrle, Nina Susanne
A1  - Schnütgen, Frank
A1  - Serve, Hubert
T1  - The clinical significance of iron overload and iron metabolism in myelodysplastic syndrome and acute myeloid leukemia
T2  - Frontiers in immunology
N2  - Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are clonal hematopoietic stem cell diseases leading to an insufficient formation of functional blood cells. Disease-immanent factors as insufficient erythropoiesis and treatment-related factors as recurrent treatment with red blood cell transfusions frequently lead to systemic iron overload in MDS and AML patients. In addition, alterations of function and expression of proteins associated with iron metabolism might are increasingly recognized to be pathogenetic factors and potential vulnerabilities of these diseases. Iron is known to be involved in multiple intracellular and extracellular processes. It is essential for cell metabolism as well as for cell proliferation and closely linked to the formation of reactive oxygen species. Therefore, iron can influence the course of clonal myeloid disorders, the leukemic environment and the occurrence as well as the defense of infections. Imbalances of iron homeostasis may induce cell death of normal but also of malignant cells. New potential treatment strategies utilizing the importance of the iron homeostasis include iron chelation, modulation of proteins involved in iron metabolism, induction of leukemic cell death via ferroptosis and exploitation of iron proteins for the delivery of antileukemic drugs.
Here, we provide a summary of some of the latest findings about the function, the prognostic impact and potential treatment strategies of iron in patients with MDS and AML.
KW  - myelodysplastic syndrome
KW  - Acute Myeloid Leukemia
KW  - Iron Overload
KW  - radical oxygen species
KW  - microenvironment
KW  - Iron chelation
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57483
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-574833
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2020.627662/abstract
SN  - 2118-9773
VL  - 11
IS  - Article 627662
SP  - 17
EP  - 18
PB  - Frontiers Media
CY  - Lausanne
ER  -