TY  - JOUR
A1  - Seibert, Marcel
A1  - Kurrle, Nina Susanne
A1  - Schnütgen, Frank
A1  - Serve, Hubert
T1  - Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation
T2  - Matrix Biology
N2  - Autophagy is the highly conserved catabolic process, which enables the survival of a cell under unfavorable environmental conditions. In a constantly changing environment, cells must be capable of dynamically oscillating between anabolism and catabolism in order to maintain cellular homeostasis. In this context, the activity of the mechanistic Target Of Rapamycin Complex 1 (mTORC1) is of major importance. As a central signaling node, it directly controls the process of macroautophagy and thus cellular metabolism. Thereby, the control of mTORC1 is equally crucial as the regulation of cellular homeostasis itself, whereby particular importance is attributed to amino acid sensory proteins. In this review, we describe the recent findings of macroautophagy and mTORC1 regulation by upstream amino acid stimuli in different subcellular localizations. We highlight in detail which proteins of the sensor complexes play a specific role in this regulation and point out additional non-canonical functions, e.g. in the regulation of macroautophagy, which have received little attention so far.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62887
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-628870
N1  - This is an Accepted Manuscript version of the following article, accepted for publication in Matrix Biology: Seibert, M.; Kurrle, N.; Schnütgen, F.; Serve, H. (2021): Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation. Matrix Biology, 100-101, p. 65-83, https://doi.org/10.1016/j.matbio.2021.01.001
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
N1  - This work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) SFB1177 (project-ID 259130777; E07 (H.S.), SFB815, project A10 (H.S.; N.K.) and by the LOEWE Center Frankfurt Cancer Institute (FCI) funded by the Hessen State Ministry for Higher Education, Research and the Arts [III L 5 - 519/03/03.001 - (0015)]
ER  -