TY  - JOUR
A1  - Bleicher, Marcus
A1  - Burigo, Lucas
A1  - Durante, Marco
A1  - Herrlitz, Maren
A1  - Krämer, Michael
A1  - Mishustin, Igor N.
A1  - Müller, Iris
A1  - Natale, Francesco
A1  - Pshenichnov, Igor A.
A1  - Schramm, Stefan
A1  - Taucher-Scholz, Gisela
A1  - Wälzlein, Cathrin
T1  - Nanolesions induced by heavy ions in human tissues: experimental and theoretical studies
T2  - Beilstein Journal of Nanotechnology
N2  - The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation. The cascade of events leading to cell death or late effects starts from stochastic energy deposition on the nanometer scale and the corresponding lesions in biological molecules, primarily DNA. We have developed experimental techniques to visualize DNA nanolesions induced by heavy ions. Nanolesions appear in cells as “streaks” which can be visualized by using different DNA repair markers. We have studied the kinetics of repair of these “streaks” also with respect to the chromatin conformation. Initial steps in the modeling of the energy deposition patterns at the micrometer and nanometer scale were made with MCHIT and TRAX models, respectively.
KW  - DNA repair
KW  - heavy ions
KW  - microdosimetry
KW  - Monte Carlo simulations
KW  - nanolesions
KW  - radiation-induced nanostructures
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/27776
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-277769
SN  - 2190-4286
N1  - This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 3
SP  - 556
EP  - 563
PB  - Beilstein-Institut zur Förderung der Chemischen Wissenschaften
CY  - Frankfurt, M.
ER  -