TY  - JOUR
A1  - Schubert-Bast, Susanne
A1  - Kaur, Moninder
A1  - Jöres, Lars
A1  - Foskett, Nadia
A1  - Roebling, Robert
A1  - Strzelczyk, Adam
T1  - Epidemiology of focal onset seizures in children aged >1 month to 4 years in Europe, United States, and Canada: A literature review
T2  - Seizure: European Journal of Epilepsy
N2  - The present study aims to report the currently available epidemiology of focal onset seizures in children aged >1 month to 4 years with the help of a literature review. The terms ‘seizure*’ OR ‘epilepsy’ combined with pediatric and epidemiology terms were used to search Embase, PubMed, and Web of Science up to November 16, 2021. Due to the scarcity of epidemiology data on focal onset seizures, the incidence and prevalence were estimated using the proportion of focal onset seizures in epilepsy patients from the most recently published articles. The estimated annual incidence per 100,000 children of focal onset seizures in children of 0–4 years of age ranged from 25.1 (95 % confidence interval [CI] 18.9–32.7) in the United Kingdom to 111.8 in the United States. The estimated period prevalence of focal onset seizures in children 0–4 years of age ranged from 0.15 % (99 % CI 0.13–0.18) in Canada to 0.61 % in the United States. Neurodevelopmental outcomes and psychiatric disorders were the most commonly reported comorbidities in children with epilepsy of age 0–4 years. Presence of focal onset seizures in children with different epilepsy syndromes needs to be thoroughly considered in the treatment planning of this population of interest.
KW  - Focal onset seizure
KW  - Epilepsy
KW  - Epidemiology
KW  - Prevalence
KW  - Incidence
KW  - Comorbidity
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77424
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-774246
SN  - 1059-1311
VL  - 112
SP  - 88
EP  - 97
PB  - Elsevier
CY  - Amsterdam
ER  -