TY  - INPR
A1  - Scheidel, Jennifer
A1  - Giese, Heiko
A1  - Schweizer, Börje
A1  - Amstein, Leonie Katharina
A1  - Ackermann, Jörg
A1  - Koch, Ina
T1  - isiKnock: in silico knockouts in biochemical pathways
T2  - bioRxiv
N2  - isiKnock is a new software that automatically conducts in silico knockouts for mathematical models of biochemical pathways. The software allows for the prediction of the behavior of biological systems after single or multiple knockout. The implemented algorithm applies transition invariants and the novel concept of Manatee invariants. A knockout matrix visualizes the results. The tool enables the analysis of dependencies, for example, in signal flows from the receptor activation to the cell response at steady state.
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72477
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-724777
IS  - 313858
ER  -