TY  - JOUR
A1  - Jemaà, Mohamed
A1  - Sime, Wondossen
A1  - Abassi, Yasmin
A1  - Lasorsa, Vito Alessandro
A1  - Køhler, Julie Bonne
A1  - Michaelis, Martin
A1  - Cinatl, Jindrich
A1  - Capasso, Mario
A1  - Massoumi, Ramin
T1  - Gene expression signature of acquired chemoresistance in neuroblastoma cells
T2  - International journal of molecular sciences
N2  - Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles.
KW  - chemoresistance
KW  - neuroblastoma
KW  - vincristine
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/55570
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-555709
SN  - 1422-0067
SN  - 1661-6596
VL  - 21
IS  - (18),  article 6811
PB  - MDPI
CY  - Basel
ER  -