TY  - INPR
A1  - Bojkova, Denisa
A1  - Costa, Rui
A1  - Bechtel, Marco
A1  - Ciesek, Sandra
A1  - Michaelis, Martin
A1  - Cinatl, Jindrich
T1  - Targeting pentose phosphate pathway for SARS-CoV-2 therapy
T2  - bioRxiv
N2  - It becomes more and more obvious that deregulation of host metabolism play an important role in SARS-CoV-2 pathogenesis with implication for increased risk of severe course of COVID-19. Furthermore, it is expected that COVID-19 patients recovered from severe disease may experience long-term metabolic disorders. Thereby understanding the consequences of SARS-CoV-2 infection on host metabolism can facilitate efforts for effective treatment option. We have previously shown that SARS-CoV-2-infected cells undergo a shift towards glycolysis and that 2-deoxy-D-glucose (2DG) inhibits SARS-CoV-2 replication. Here, we show that also pentose phosphate pathway (PPP) is remarkably deregulated. Since PPP supplies ribonucleotides for SARS-CoV-2 replication, this could represent an attractive target for an intervention. On that account, we employed the transketolase inhibitor benfooxythiamine and showed dose-dependent inhibition of SARS-CoV-2 in non-toxic concentrations. Importantly, the antiviral efficacy of benfooxythiamine was further increased in combination with 2DG.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72816
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-728166
IS  - 2020.08.19.257022
ER  -