TY  - JOUR
A1  - Alves, Gilberto Sousa
A1  - O’Dwyer, Laurence
A1  - Jurcoane, Alina
A1  - Oertel-Knöchel, Viola
A1  - Knöchel, Christian
A1  - Prvulovic, David
A1  - Sudo, Felipe
A1  - Alves, Carlos Eduardo
A1  - Valente, Letice
A1  - Moreira, Denise
A1  - Fußer, Fabian
A1  - Karakaya, Tarik
A1  - Pantel, Johannes
A1  - Engelhardt, Eliasz
A1  - Laks, Jerson
T1  - Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients
T2  - PLoS One
N2  - Alzheimeŕs disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM). In the current study, multiple indices of diffusion tensor imaging (DTI) and brain volumetric measurements were employed to comprehensively investigate the landscape of AD pathology. The sample comprised 58 individuals including cognitively normal subjects (controls), amnestic mild cognitive impairment (MCI) and AD patients. Relative to controls, both MCI and AD subjects showed widespread changes of anisotropic fraction (FA) in the corpus callosum, cingulate and uncinate fasciculus. Mean diffusivity and radial changes were also observed in AD patients in comparison with controls. After controlling for the gray matter atrophy the number of regions of significantly lower FA in AD patients relative to controls was decreased; nonetheless, unique areas of microstructural damage remained, e.g., the corpus callosum and uncinate fasciculus. Despite sample size limitations, the current results suggest that a combination of secondary and primary degeneration occurrs in MCI and AD, although the secondary degeneration appears to have a more critical role during the stages of disease involving dementia.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28363
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-283639
SN  - 1932-6203
N1  - Copyright: © 2012 Alves et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 7
IS  - (12): e52859
PB  - PLoS
CY  - Lawrence, Kan.
ER  -