TY  - INPR
A1  - Hatton, Sean N.
A1  - Huynh, Khoa H.
A1  - Bonilha, Leonardo
A1  - Abela, Eugenio Cecilio
A1  - Alhusaini, Saud
A1  - Altmann, André
A1  - Alvim, Marina K. M.
A1  - Balachandra, Akshara R.
A1  - Bartolini, Emanuele
A1  - Bender, Benjamin
A1  - Bernasconi, Neda
A1  - Bernasconi, Andrea
A1  - Bernhardt, Boris
A1  - Bargallo, Núria
A1  - Caldairou, Benoit
A1  - Caligiuri, Maria Eugenia
A1  - Carr, Sarah J. A.
A1  - Cavalleri, Gianpiero L.
A1  - Cendes, Fernando
A1  - Concha, Luis
A1  - Davoodi-Bojd, Esmaeil
A1  - Desmond, Patricia M.
A1  - Devinsky, Orrin
A1  - Doherty, Colin P.
A1  - Domin, Martin
A1  - Duncan, John S.
A1  - Focke, Niels K.
A1  - Foley, Sonya F.
A1  - Gambardella, Antonio
A1  - Gleichgerrcht, Ezequiel
A1  - Guerrini, Renzo
A1  - Hamandi, Khalid
A1  - Ishikawa, Akari
A1  - Keller, Simon S.
A1  - Kochunov, Peter V.
A1  - Kotikalapudi, Raviteja
A1  - Kreilkamp, Barbara A. K.
A1  - Kwan, Patrick
A1  - Labate, Angelo
A1  - Langner, Sönke
A1  - Lenge, Matteo
A1  - Liu, Min
A1  - Lui, Elaine
A1  - Martin, Pascal
A1  - Mascalchi, Mario
A1  - Moreira, José Carlos Vasques
A1  - Morita-Sherman, Marcia Elisabete
A1  - O’Brien, Terence J.
A1  - Pardoe, Heath R.
A1  - Pariente Zorrilla, José Carlos
A1  - Ribeiro, Letı́cia F.
A1  - Richardson, Mark Philip
A1  - Rocha, Cristiane S.
A1  - Rodrı́guez-Cruces, Raúl
A1  - Rosenow, Felix
A1  - Severino, Mariasavina
A1  - Sinclair, Benjamin
A1  - Soltanian-Zadeh, Hamid
A1  - Striano, Pasquale
A1  - Taylor, Peter N.
A1  - Thomas, Rhys H.
A1  - Tortora, Domenico
A1  - Velakoulis, Dennis
A1  - Vezzani, Annamaria
A1  - Vivash, Lucy
A1  - Podewils, Felix von
A1  - Vos, Sjoerd B.
A1  - Weber, Bernd
A1  - Winston, Gavin P.
A1  - Yasuda, Clarissa L.
A1  - Thompson, Paul M.
A1  - Jahanshad, Neda
A1  - Sisodiya, Sanjay M.
A1  - McDonald, Carrie R.
T1  - White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA Epilepsy study
T2  - bioRxiv
N2  - The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analyzed from 1,069 non-epileptic controls and 1,249 patients: temporal lobe epilepsy with hippocampal sclerosis (N=599), temporal lobe epilepsy with normal MRI (N=275), genetic generalized epilepsy (N=182) and nonlesional extratemporal epilepsy (N=193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fiber tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at p<0.001). Across “all epilepsies” lower fractional anisotropy was observed in most fiber tracts with small to medium effect sizes, especially in the corpus callosum, cingulum and external capsule. Less robust effects were seen with mean diffusivity. Syndrome-specific fractional anisotropy and mean diffusivity differences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal cingulum and external capsule, with smaller effects across most other tracts. Those with temporal lobe epilepsy and normal MRI showed a similar pattern of greater ipsilateral than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis. Patients with generalized and extratemporal epilepsies had pronounced differences in fractional anisotropy in the corpus callosum, corona radiata and external capsule, and in mean diffusivity of the anterior corona radiata. Earlier age of seizure onset and longer disease duration were associated with a greater extent of microstructural abnormalities in patients with hippocampal sclerosis. We demonstrate microstructural abnormalities across major association, commissural, and projection fibers in a large multicentre study of epilepsy. Overall, epilepsy patients showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes. These data further define the spectrum of white matter abnormalities in common epilepsy syndromes, yielding new insights into pathological substrates that may be used to guide future therapeutic and genetic studies.
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72674
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-726746
IS  - 2019.12.19.883405
ER  -