TY  - JOUR
A1  - Colvill, Emma
A1  - Booth, Jeremy
A1  - Nill, Simeon
A1  - Fast, Martin
A1  - Bedford, James
A1  - Oelfke, Uwe
A1  - Nakamura, Mitsuhiro
A1  - Poulsen, Per
A1  - Worm, Esben
A1  - Hansen, Rune
A1  - Ravkilde, Thomas
A1  - Rydhög, Jonas Scherman
A1  - Pommer, Tobias
A1  - Munck af Rosenschold, Per
A1  - Lang, Stephanie
A1  - Guckenberger, Matthias
A1  - Groh, Christian
A1  - Herrmann, Christian
A1  - Verellen, Dirk
A1  - Poels, Kenneth
A1  - Wang, Lei
A1  - Hadsell, Michael
A1  - Sothmann, Thilo
A1  - Blanck, Oliver
A1  - Keall, Paul
T1  - A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy : a multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking
T2  - Radiotherapy and oncology
N2  - Purpose: A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion.
Methods and materials: Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT and structure sets, motion traces and planning protocols to create a lung and a prostate plan. For each motion trace, the plan was delivered twice to a moving dosimeter; with and without real-time adaptation. Each measurement was compared to a static measurement and the percentage of failed points for γ-tests recorded.
Results: For all lung traces all measurement sets show improved dose accuracy with a mean 2%/2 mm γ-fail rate of 1.6% with adaptation and 15.2% without adaptation (p < 0.001). For all prostate the mean 2%/2 mm γ-fail rate was 1.4% with adaptation and 17.3% without adaptation (p < 0.001). The difference between the four systems was small with an average 2%/2 mm γ-fail rate of <3% for all systems with adaptation for lung and prostate.
Conclusions: The investigated systems all accounted for realistic tumor motion accurately and performed to a similar high standard, with real-time adaptation significantly outperforming non-adaptive delivery methods.
KW  - Robotic tracking
KW  - Gimbaled tracking
KW  - MLC tracking
KW  - Couch tracking
KW  - Organ motion
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43019
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-430196
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854175
SN  - 1879-0887
SN  - 0167-8140
N1  - © 2016 The Authors. Published by Elsevier Ireland Ltd. Radiotherapy and Oncology 119 (2016) 159–165 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/).
VL  - 119
IS  - 1
SP  - 159
EP  - 165
PB  - Elsevier Science
CY  - Amsterdam [u. a.]
ER  -