TY  - JOUR
A1  - Valek, Lucie
A1  - Kanngießer, Maike
A1  - Tegeder, Irmgard
T1  - Expression and regulation of redoxins at nociceptive signaling sites after sciatic nerve injury in mice
T2  - Data in Brief
N2  - Injury of the sciatic nerve results in regulations of pro- and anti-oxidative enzymes at sites of nociceptive signaling including the injured nerve, dorsal root ganglia (DRGs), dorsal horn of the spinal cord, thalamus and somatosensory cortex (Valek et al., 2015) [1]. The present DiB paper shows immunohistochemistry of redoxins including peroxiredoxins (Prdx1–6), glutaredoxins (Glrx1, 2, 3, 5), thioredoxins (Txn1, 2) and thioredoxin reductases (Txnrd1, 2) in the DRGs, spinal cord and sciatic nerve and thalamus in naïve mice and 7 days after Spared sciatic Nerve Injury (SNI) in control mice (Hif1α-flfl) and in mice with a specific deletion of hypoxia inducible factor 1 alpha (SNS-HIF1α−/−) in DRG neurons. The sciatic nerves were immunostained for the respective redoxins and counterstained with hematoxylin. The redoxin immunoreactivity was quantified with ImageJ. For the DRGs and spinal cord the data show the quantitative assessment of the intensity of redoxin immunoreactivity transformed to rainbow pseudocolors. In addition, some redoxin examples of the ipsi and contralateral dorsal and ventral horns of the lumbar spinal cord and some redoxin examples of the thalamus are presented.
KW  - Redoxin
KW  - Hypoxia inducible factor 1 alphal
KW  - Dorsal root ganglia
KW  - Spinal cord
KW  - Immunohistochemistry
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75921
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-759218
SN  - 2352-3409
VL  - 5
SP  - 834
EP  - 845
PB  - Elsevier
CY  - Amsterdam
ER  -