TY  - JOUR
A1  - Wittko-Schneider, Ina M.
A1  - Schneider, Fabian T.
A1  - Plate, Karl
T1  - Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind
T2  - Cellular and molecular life sciences
N2  - Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood. Therefore, the VEGF system serves as a promising therapeutic target for brain pathologies, but its simultaneous action on vascular cells paves the way for harmful side effects. To circumvent these deleterious effects, many studies have aimed to clarify whether VEGFs directly affect neural cells or if the effects are mediated secondarily via other cell types, like vascular cells. A great number of reports have shown the expression and function of VEGF receptors (VEGFRs), mainly VEGFR-1 and -2, in neural cells, where VEGFR-2 has been described as the major mediator of VEGF-A signals. This review aims to summarize and compare the divergent roles of VEGFR-1 and -2 during CNS development and homeostasis.
KW  - VEGF receptors
KW  - Neurogenesis
KW  - Neural stem cells
KW  - Brain development
KW  - Brain repair
KW  - Migration
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/29144
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-291443
SN  - 1420-682X
SN  - 1420-9071
N1  - Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
VL  - 70
IS  - 10
SP  - 1705
EP  - 1725
PB  - Birkhäuser
CY  - Basel
ER  -