TY  - JOUR
A1  - Beck, Karl-Friedrich
A1  - Pfeilschifter, Josef
T1  - The pathophysiology of H2S in renal glomerular diseases
T2  - Biomolecules
N2  - Renal glomerular diseases such as glomerulosclerosis and diabetic nephropathy often result in the loss of glomerular function and consequently end-stage renal disease. The glomerulus consists of endothelial cells, mesangial cells and glomerular epithelial cells also referred to as podocytes. A fine-tuned crosstalk between glomerular cells warrants control of growth factor synthesis and of matrix production and degradation, preserving glomerular structure and function. Hydrogen sulfide (H2S) belongs together with nitric oxide (NO) and carbon monoxide (CO) to the group of gasotransmitters. During the last three decades, these higher concentration toxic gases have been found to be produced in mammalian cells in a well-coordinated manner. Recently, it became evident that H2S and the other gasotransmitters share common targets as signalling devices that trigger mainly protective pathways. In several animal models, H2S has been demonstrated as a protective factor in the context of kidney disorders, in particular of diabetic nephropathy. Here, we focus on the synthesis and action of H2S in glomerular cells, its beneficial effects in the glomerulus and its action in the context of the other gaseous signalling molecules NO and CO.
KW  - hydrogen sulfide (H2S)
KW  - gasotransmitters
KW  - glomerulus
KW  - mesangial cells
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/82496
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-824967
SN  - 2218-273X
N1  - This work was supported by the German Research Foundation (SFB 815, SFB 1039, EXC 115, EXC 147 and PF361/7-1).
VL  - 12
IS  - 2, art. 207
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel
ER  -