TY  - JOUR
A1  - Wisniewska, Joanna Marta
A1  - Jäger, Natalie
A1  - Freier, Anja
A1  - Losch, Florian O.
A1  - Wiesmüller, Karl-Heinz
A1  - Walden, Peter
A1  - Wrede, Paul
A1  - Schneider, Gisbert
A1  - Hiß, Jan Alexander
T1  - MHC I stabilizing potential of computer-designed octapeptides
T2  - Journal of biomedicine and biotechnology
N2  - Experimental results are presented for 180 in silico designed octapeptide sequences and their stabilizing effects on the major histocompatibility class I molecule H-2Kb. Peptide sequence design was accomplished by a combination of an ant colony optimization algorithm with artificial neural network classifiers. Experimental tests yielded nine H-2Kb stabilizing and 171 nonstabilizing peptides. 28 among the nonstabilizing octapeptides contain canonical motif residues known to be favorable for MHC I stabilization. For characterization of the area covered by stabilizing and non-stabilizing octapeptides in sequence space, we visualized the distribution of 100,603 octapeptides using a self-organizing map. The experimental results present evidence that the canonical sequence motives of the SYFPEITHI database on their own are insufficient for predicting MHC I protein stabilization.
Y1  - 2010
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/8109
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-80618
SN  - 1110-7243
N1  - Copyright © 2010 Joanna M.Wisniewska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2010
IS  - Article ID 396847
SP  - 1
EP  - 9
PB  - Hindawi
CY  - New York, NY
ER  -