TY  - JOUR
A1  - Conradi, Nadine Caroline
A1  - Rosenberg, Friederike
A1  - Knake, Susanne
A1  - Biermann, Louise
A1  - Haag, Anja
A1  - Gorny, Iris
A1  - Hermsen, Anke Maria
A1  - Podewils, Viola Lara von
A1  - Behrens, Marion
A1  - Gurschi, Marianna
A1  - du Mesnil de Rochemont, Richard Klaus Frieder
A1  - Menzler, Katja
A1  - Bauer, Sebastian
A1  - Schubert-Bast, Susanne
A1  - Nimsky, Christopher
A1  - Konczalla, Jürgen
A1  - Rosenow, Felix
A1  - Strzelczyk, Adam
T1  - Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery
T2  - Scientific reports
N2  - In recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with temporal lobe epilepsy who underwent WT and subsequent surgery were analyzed retrospectively. Additionally, a standard neuropsychological assessment evaluating attentional, learning and memory, visuospatial, language, and executive function was performed both before and 12 months after surgery. Hierarchical linear regression analyses were used to determine the incremental value of WT results over socio-demographic, clinical, and neuropsychological characteristics in predicting postsurgical change in patients’ verbal learning and verbal memory function. The incorporation of WT results significantly improved the prediction models of postsurgical change in verbal learning (∆R2 = 0.233, p = .032) and verbal memory function (∆R2 = 0.386, p = .005). Presurgical performance and WT scores accounted for 41.8% of the variance in postsurgical change in verbal learning function, and 51.1% of the variance in postsurgical change in verbal memory function. Our findings confirm that WT results are of significant incremental value for the prediction of postsurgical change in verbal learning and verbal memory function. Thus, the WT contributes to determining the risks of epilepsy surgery and, therefore, remains an important part of the presurgical work-up of selected patients with clear clinical indications.
KW  - Epilepsy
KW  - Neurology
KW  - Psychology
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75077
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-750771
SN  - 2045-2322
N1  - The authors were supported by the LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany, funded by The Hessen State Ministry for Higher Education, Research and the Arts (HMWK), and by the Detlev-Wrobel-Fonds for Epilepsy Research.
Open Access funding enabled and organized by Projekt DEAL.
VL  - 11
IS  - art. 10979
SP  - 1
EP  - 10
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - [London]
ER  -